23 results
diagnosis differential oncology management algorithm hemolysis dermatology extravascular intravascular leukemia product reactions workup agglutinin aplastic calculation cellulitis chronic cirrhosis clinical
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Sickle cell ... circulation - Infections ... anemia • ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... drug induced • Infections ... #classification ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
(e.g. cancer, infection ... Microangiopathic hemolytic ... defects (e.g. sickle cell ... ), Infections, Hypersplenism ... Production #Index #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... #MCV #Classification ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... pain, bleeding, infections ... - infiltrates (anemia ... #Leukemia #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... malignancies • Anemia ... iron deficiency, hemolysis ... myeloid leukemia (CML ... #hematology #secondary
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... Lymphocytosis: Absolute blood ... lymphocyte > 5000/microL ... • Neutropenia, anemia ... workup #oncology #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Internal (RBC) - Infections ... anemia, Thalassemias ... - Peripheral Blood ... Differential #Diagnosis #hematology
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