33 results
differential anemia oncology management algorithm rheumatology dermatology hemolysis workup extravascular intravascular leukemia product reactions syndrome vasculitis agep agglutinin allergy aplastic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... Extravascular #Causes ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... • Sickle cell ... circulation - Infections ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... #causes #classification ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... malignancies -> CLL ... sensitize red blood ... #anemia #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... pain, bleeding, infections ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential Diagnosis ... Algorithm Infectious ... Serum Sickness Hemolytic ... Disease • Sickle Cell ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... Diagnosis: • ... Lymphocytosis: Absolute blood ... lymphocyte > 5000/microL ... workup #oncology #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... #Anemia #MCV #Classification ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
(e.g. cancer, infection ... Microangiopathic hemolytic ... defects (e.g. sickle cell ... Production #Index #hematology ... #differential #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... myeloid leukemia (CML ... #Causes #hematology
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