43 results
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
Effects Diuresis, Na ... Thiazide Type - Loop ... electrolytes #effects #pharmacology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Metolazone Loop ... #Diuretics #Pharmacology ... nephrology #conversion #loop ... #thiazide #classes
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
65% of filtered Na ... organic acids and bases ... limb of Henle's loop ... limb of Henle's loop ... Tubules #Table #Pharmacology
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Treat underlying cause ... : • Causes can ... • With lower Na ... administered • Can cause ... ascending limb of the loop
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Workup: - ANA ... > - Anti-ENA ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... practices that could cause ... function test, ANA ... patients if the cause ... #Workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... Workup: - ANA ... Discontinuation of causal ... Positive in 60-80% of cases ... comparison #table #rheumatology
SIADH Treatment Options
1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
Treat underlying cause ... • With lower Na ... administered • This can cause ... ascending limb of the loop ... Re-check the serum Na
Causes of Hypomagnesemia - Differential Diagnosis Algorithm
GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... Urine Mg > 10g • Loop ... Genetics defects in Na-KATPase ... Magnesium #Low #Causes
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... : Urine Common Uses ... rapid injection; Nausea ... #Indications #Pharmacology ... #hematology