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diagnosis classification workup algorithm arthritis causes erythematosus joint lupus management msk oncology pain signs sle symptoms systemic vasculitis agglutinin ascites
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... : Acute blood loss ... hemolysis, deficiency anemia ... Diagnosis #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach ... to Anemia - Differential ... Diagnosis Algorithm Blood ... Disease • Marrow ... Algorithm #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
(Morphological Approach ... chronic kidney disease ... , Acute blood loss ... morphologic #mcv #differential ... diagnosis #causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
long (in days) it takes ... the peripheral blood ... Chronic kidney disease ... Production #Index #hematology ... #anemia #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... - Hemolytic anemia ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... pain (20%) Renal disease ... (75%): Anemia ( ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Ascites - Diagnostic Approach and Differential Diagnosis The most common causes: cirrhosis, malignancy and heart failure. Approx
Ascites - Diagnostic Approach ... dullness, puddle sign ... incisional). 3) Signs ... of underlying disease ... #Diagnosis #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Immunoglobulin M (IgM) • Blood ... younger pts) Differential ... sensitize red blood ... Symptoms: High fevers ... #hematology #diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... • Autoimmune diseases ... tachycardia or fever ... #differential # ... neutrophil #WBC #CBC #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint ... acute rheumatic fever ... ), RA, crystal disease ... Joint #Pain #MSK #rheumatology ... #differential #
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