1750 results
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Cell Disease • Decreases ... 4.5 vs. 2.4) • Decreases ... organ benefit and decreased ... pathophysiology #pharmacology
COMMONLY ENCOUNTERED MEDICATIONS THAT INCREASE OR DECREASE WARFARIN’S INTERNATIONAL NORMALIZED RATIO (INR)

#Pharmacology #Warfarin #Medications #Interactions #INR
THAT INCREASE OR DECREASE ... RATIO (INR) #Pharmacology ... INR #Increases #Decreases
Adverse Effects of NSAIDs
Prostaglandins decreased
 - Gastric mucosal damage with ulcer formation, bleeding, and perforation
 -
Prostaglandins decreased ... - Nephropathy, decreased ... and H2O, edemas, increased ... Leukotrienes increased ... #SideEffects #Pharmacology
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Excretion Decreased ... , Pentamidine Decreased ... Ketoconazole Decreased ... Beta-Blockers Decreased ... Pathophysiology #Pharmacology
Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis

 - Renal disease, Cardiovascular disease -> Decreased renal
Cardiovascular disease -> Decreased ... , Diuretics -> Decreased ... blood volume -> Increased ... Prostaglandins #Pharmacology
Pharmaceutical Management of Hyperthyroidism / Thyroid Storm
Beta-Blockers 
• Decreases sympathetic hyperactivity 
• Partially blocks peripheral conversion
Beta-Blockers • Decreases ... thyroid hormone • Decreases ... Steroids • Decrease ... ThyroidStorm #Management #Pharmacology
NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk
- Celecoxib • Increased ... for CV events • Decreased ... in patients at increased ... Ibuprofen, naproxen • Decreased ... selectivity #spectrum #pharmacology
Calcium Channel Blockers - Dihydropyridines vs Non-Dihydropyridines
Dihydropyridines (amlodipine, felodipine, nifedipine, nicardipine)
 • SVR: Decrease
 • Inotropy:
nicardipine) • SVR: Decrease ... verapamil) • SVR: Decrease ... • Inotropy: Decrease ... NonDihydropyridines #pharmacology
Pharmacologic Options for Hypercalcemia Associated with Cancer
Rehydration with NS followed by loop diuretics
 • IV normal
Pharmacologic Options ... osteoclast activity; decreases ... Inhibits RANKL to decrease ... drugs #treatment #pharmacology
Alternatives to opioids for pain management in the emergency department decreases opioid usage and maintains patient
emergency department decreases ... #Management #Pharmacology