22 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... of anemia and hemolysis ... Autoimmune Hemolytic Anemias ... #Hemolytic #Anemias
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... anemia - Anemia ... inflammation - Anemia ... #diagnosis #differential ... #workup
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic Anemia ... • 812, Folate Deficiency ... #Macrocytic #Anemia ... #differential # ... #workup
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... ARUPLabs #Hemolytic #Anemia ... Diagnosis #Algorithm #workup ... #hematology #testing
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
E - Haemolytic anaemia ... paraesthesiae • Folate - Anaemia ... Vitamin B12 - Anaemia ... #differential # ... diagnosis #signs
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... failure: Aplastic anemia ... Intrinsic RBC defects ... #anemia #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... • G6PD deficiency ... • PK deficiency ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
scapularis • Infects ... within morulae Signs ... myalgias, shaking chills ... immature forms) • Anemia
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
suspected: • Signs ... disease • Iron-deficiency ... anemia unresponsive ... discernable cause • Signs ... microscopic colitis Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Intrinsic RBC Defects ... G6PD deficiency) ... Extravascular #Causes #differential ... #anemia