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diagnosis comparison anemia causes hemolytic algorithm classification hemolysis management platelet thrombocytopenia vasculitis aflp disorders extravascular hellp intravascular obstetrics pregnancy treatment
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Diagnosis Algorithm Signs ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects ... Diagnosis #Algorithm #hematology
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
vessel vasculitis affects ... predominantly affects ... predominantly affects ... #Diagnosis #Rheumatology ... #Differential #
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... Abnormal Hgb & Hgb Defects ... Hgb - Membrane Defects ... - RBC Enzyme Defects ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Thrombocytopenia • Platelet defects ... PURPURA: Platelet Defects ... syndrome Coagulation Defects ... #Diagnosis #hematology ... #rheumatology #
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... Inherited #Platelet #Defects ... #comparison #table ... #differential # ... diagnosis #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
with coagulation defects ... Severe coagulation defects ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... , Other enzyme defects ... Unstable hemoglobin defects ... Glutathione metabolism defects ... Algorithm #workup #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
with coagulation defects ... Severe coagulation defects ... AFLP #obstetrics #hematology ... #diagnosis #table
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
• Generally affects ... necrosis: • Affects ... • Differentiate ... SickleCell #Disease #differential ... diagnosis #causes #hematology
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