7 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... Diagnosis Algorithm Signs ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC) - HELLP ... Intrinsic RBC Defects ... thalassemias), Membrane defects ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... , Other enzyme defects ... Unstable hemoglobin defects ... Glutathione metabolism defects ... thrombocytopenia - DIC, TTP, HELLP
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... TTP, HUS, DIC, HELLP ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... AFLP #obstetrics #hematology ... #diagnosis #table
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
with coagulation defects ... . 1) HELLP (Hemolysis ... Severe coagulation defects ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... TTP, HUS, DIC, HELLP ... classification #hematology