28 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... Diagnosis Algorithm ... Signs of anemia ... #Diagnosis #Algorithm ... #hematology
Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
and Symptoms of ... Hemolytic Anemia ... #Anemia #hematology ... #diagnosis #signs ... #symptoms
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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- Differential ... Diagnosis Algorithm ... Extravascular #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Intrinsic RBC Defects ... thalassemias), Membrane defects ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Urobilinogen #Hemolysis ... #Differential # ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... , spider/snake bites ... classification #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... DIC/TTP/HUS - Hemolytic ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Microangiopathic hemolytic ... Intrinsic RBC defects ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
(Cold-induced symptoms ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology ... #diagnosis