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diagnosis differential algorithm macrocytosis elevatedmcv platelets aafp blood disorders folate folicacid homocysteine markers mcv mds microcytic mma morphologic myelodysplasia myelodysplastic
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... diagnosis #algorithm #hematology ... #workup
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... , Folate deficiency ... differential #diagnosis #causes ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... specifically: iron deficiency ... Differential #Diagnosis #Causes ... #hematology #secondary
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... B12 and Folate Deficiency ... #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... blood loss (Fe deficiency ... Differential #Diagnosis #causes ... #Platelets #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes ... Polychromatic Macrocytes ... • Early Iron Deficiency ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... for workup, including ... Acute hemolysis, deficiency ... anemia, Rebound
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... if vitamin B12 deficiency
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Pseudo Pelger-Huet, Macrocytic ... anemia - ... PV), Essential Thrombocytosis ... (MF), Reactive Thrombocytosis ... Blood #Disorders #hematology
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