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differential hematology pediatrics causes monoclonal mgus alte apml bleeding brue clinical developmentaldelay differentiation disorders event failuretothrive floppy ftt gammopathies gammopathy
Causes of Developmental Delay - Differential Diagnosis Algorithm Isolated Domain Delay - Reduced Respiratory Drive: • Cognitive
Algorithm Isolated ... Developmental Delay: • Syndromic ... Landau-Kleffner Syndrome ... Mechanical (e.g. dental ... #Peds #Pediatrics
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... capillary leak syndrome ... • Schnitzler syndrome ... #Differential #Diagnosis ... #hematology #oncology
Causes of Apparent Life Threatening Event (ALTE) - Differential Diagnosis Algorithm Cardiac: • Congenital Heart Disease •
- Differential Diagnosis ... Algorithm Cardiac ... Metabolism • Reye's Syndrome ... Disorders • Central ... #Peds #Pediatrics
Causes of Failure to Thrive - Differential Diagnosis Algorithm Adequate Calorie Consumption - Increased Losses:
- Differential Diagnosis ... Algorithm Adequate ... Disorders • Syndromes ... #Algorithm #Causes ... #Peds #Pediatrics
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Hyperviscosity syndrome ... CVST • Bing-Neel syndrome ... (Dermato-neuro syndrome ... Thrombosis in vascular beds-renal
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
- Differential Diagnosis ... Algorithm Central ... Other Congenital Syndromes ... #Algorithm #Causes ... #Peds #Pediatrics
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Anaphylaxis, Acute Renal ... Differentiation #Syndrome ... #management #hematology ... #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... (CML) • Felty Syndrome ... #diagnosis #hematology ... #oncology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
procedures and dental ... Marfan syndrome, ... Disorders #History #peds ... #pediatrics #diagnosis ... #hematology #primarycare
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