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diagnosis anemia algorithm extravascular intravascular management oncology allergy antibody criteria definitions dermatology enlarged eosinophilia erythematosus eularacr high hodgkins hyperkalemia hypersensitivity
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
surfaces • Ex: Autoimmune ... Hemolytic anemia ... • Ex: Systemic Lupus ... Syndrome, Contact Dermatitis ... #Types #Classification
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... reticulocytes • Hemolysis ... 2) LOOK FOR a cause ... #Hemolytic #Anemia ... management #treatment #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... #Hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential ... Dermatitis - ... (vasculitis / autoimmune ... #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Inflammatory and Autoimmune ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... hemolysis • Renal ... Erythematosus #diagnosis #rheumatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... udaygulati #Hemolytic ... #classification ... #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Inflammatory • Systemic Lupus ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... #hematology #secondary
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