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anemia algorithm blood eosinophilia eosinophils myelodysplastic product aplastic apml atopic atopy differentiation eczema extravascular he hemolysis hodgkins hypereosinophilic intravascular lymphoma
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
and Treatment Algorithm ... Matthew Ho, MD ... #Syndrome #HES ... #Hematology #eosinophilia ... #management #algorithm
Hypereosinophilia (HE) Summary • Definition • When to Suspect? • A Partial Classification of Hypereosinophilia •
• A Partial Classification ... Presentations • Treatment ... Zhuoer Xie, MD ... #HE #hematology ... #diagnosis #management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... (HUS) • Other ... #differential # ... diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • Transfusion reactions ... #Diagnosis #causes ... #classification ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic ... fever • Drug reactions ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
(MD) - Diagnosis ... old, ~10,000 new cases ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... Syndrome (HES) ... eosinophilia Secondary Causes ... #Syndrome #HES ... #hematology #differential
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... Occurs between 0-6 hrs ... infographic by Nick Mark MD ... #Transfusion #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... febrile neutrophilic dermatosis ... initiation • Differential ... #management #hematology ... #oncology
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