11 results
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... Neutrophilic dermatosis ... dermatomyositis, SLE ... leukocytoclastic vasculitis ... #dermatology #oncology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
(10%) : SLE +++ ... #dermatology #semiology ... #signs #lesions ... #diagnosis #clinical ... #manifestations
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
lesions • Mononeuritis ... such as systemic lupus ... Presentation - Systemic Symptoms ... purpura: strong sign ... , and SLE) • Urinalysis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... lesions and plaques ... inflammation on skin ... Livedo Reticularis, Vasculitis ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... panuveitis, retinal vasculitis ... ) • Cutaneous Lesions ... MCC-small vessel vasculitis ... #symptoms #rheumatology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Episcleritis Signs ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus ... #dermatology #oncology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... • Progressive symptoms ... : • Skin lesions ... #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... papulosquamous lesions ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Vasculitis: •
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... Paraproteinemias #Hematology ... #Oncology