33 results
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... • Systemic lupus ... #neurology #inflammatory ... #differential # ... diagnosis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... SLE), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis ... #differential
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... lupus erythematosus ... (SLE) Signs / ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... #signs #symptoms ... #mimickers #differential
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders - Differential ... Diagnosis Algorithm ... arthritis - (Reiter’s syndrome ... Lupus - with Systemic ... should have other symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Demyelinating syndromes ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Diagnosis for Pulmonary ... Immune Complex: Systemic ... lupus erythematosus ... #differential # ... diagnosis #nephrology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
autoimmune disorders (Systemic ... lupus erythematosus ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
and signs below ... Sarcoidosis, Behcet disease ... , Scleroderma, Systemic ... MCTD, Sjogren syndrome ... #neurology #differential
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... IgG • Lupus anticoagulant ... Hematology #Monoclonal #Differential ... #Diagnosis #Oncology