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management chronic classification cll differential lymphocytic mds myelodysplastic syndrome aplastic cancer coagulation dic disorders disseminated hemeonc hodgkins intravascular lymphoma lymphomas
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Algorithm #Causes ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... #Management #treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... chemotherapy for low-risk disease ... marrow failure with anemia ... #oncology #hematology ... #hemeonc #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Algorithm Hodgkin ... pattern of spread, B symptoms ... Treated Like Acute Leukemias ... Classification #pathophysiology ... #Hematology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Causes: - Idiopathic ... , breast CA - Hematologic ... Treatment: - Systemic ... #dermatology #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... • Severe Liver Disease ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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