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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... Coagulation (DIC ... INR < 2.3 - APTT ... #Disseminated # ... treatment #management #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Scoring System for Disseminated ... (DIC) Platelet ... aggregation PT, aPTT ... #Disseminated # ... Scoring #diagnosis #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology ... #coagulation
Management of Disseminated intravascular coagulation (DIC)

#DIC #Disseminated #intravascular #coagulation #Management #Hematology
Management of Disseminated ... intravascular coagulation ... (DIC) #DIC # ... #coagulation #Management ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
the PT and the aPTT ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
endocarditis) - Disseminated ... intravascular coagulation ... (DIC) INFLAMMATORY ... APLS:PLT ↓ HEMATOLOGIC ... MAHA: TTP, HUS, DIC
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... conditions such as disseminated ... intravascular coagulation ... count, D-dimer, egg ... hemolytic #anemia #Hematology
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC ... LaboratoryFindings #Disseminated ... Intravascular #Coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Rare • Drugs (e.g ... • Vasculitis Coagulation ... deficiencies Coagulation ... Deficiency • Disseminated ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... (usually IgG) (e.g ... differential #diagnosis #hematology