35 results
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
• Secondary (e.g ... Macrocytes, Normal RBCs ... Spherocytes, RBC ... ) - Abnormal RBCs ... Algorithm #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... Iron Deficiency (Eg ... Other • e.g ... HgbE, HgbC, etc. ... Algorithm #Causes #Hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
• Provoked (e.g ... - No other workup ... cancer screening, CBC ... #hematology #diagnosis ... #algorithm #hematology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(MCV): Average RBC ... among size of RBCs ... of substrate (e.g ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Post-splenectomy, Etc ... Liver disease, Etc ... valve induced, Etc ... differential #diagnosis #hematology
Consensus Indications for Irradiated RBC Transfusions:

Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
for Irradiated RBC ... antithymocyte globulin, etc ... HLA-selected products (e.g ... #Irradiation #RBC ... #Indications #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... • Intrinsic RBC ... deficiencies (e.g ... differential #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Neutrophils - Low RBC ... Increased Requirement (e.g ... Pernicious Anemia RBCs ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Polymyositis / Dermatomyositis ... biliary cirrhosis (PBC ... - Vasculitis, e.g ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... function test, ANA (e.g ... or if a primary hematologic ... Diagnosis #Causes #Workup ... #hematology