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differential causes erythematosus management sle symptoms workup systemic activation algorithm arteritis arthritis atlas autoantibodies bloodcell chronic cll disease disorders electrophoresis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... NEUROLOGIC - HEMOLYTIC ANEMIA ... (<1000/MM3) - THROMBOCYTOPENIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Glomerulonephritis Myositis(5%) Blood ... (75%): Anemia ( ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... microangiopathy: Thrombotic thrombocytopenic ... . lupus, CLL, lymphoma ... #hematology #anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... autoantibodies #signs ... #differential #rheumatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Chemotherapy (e.g ... disease, McLeod blood ... #differential #diagnosis ... #hematology #microscopy
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... plateletcount), peripheral blood ... function test, ANA (e.g ... changes), high MCV anemia ... Causes #Workup #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Differential Diagnosis ... Causes: Chronic Blood ... HgbE, HgbC, etc. ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
with leukopenia, anemia ... , and thrombocytopenia ... Histopathologic criteria ... #Management #Hematology ... #Rheumatology
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
chemotherapy, etc ... • New-onset anemia ... on peripheral blood ... Electrophoresis #SPEP #Hematology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... , thrombocytopenia ... workup #oncology #hematology
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