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Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
post-hypothermia • ↓ Renal ... Excretion: - Renal ... heparinized tube) • ECG ... 15 suggests ↓ renal ... Elimination (see Table
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
irrigation • Management ... Torsemide) • Acute pulmonary ... Hyponatremia • Hypercalcemia ... Tolvaptan) • Treatment ... #Medications #Table
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... Herpes, Coxsackie, etc ... per day until stable ... Loop diuretics for ... Differential #Diagnosis #Management
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Diagnosis and Management ... Herpes, Coxsackie etc ... per day until stable ... Loop diuretics for ... Dialysis for severe hyperkalemia
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... ECG changes, weakness ... , K+ >6.5 Or renal ... ) ECG changes ... #Management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
syndrome • Triggers: Diuretics ... hydration - Hyperkalemia ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
: 33% • Treatment ... , and CXR with pulmonary ... : Supportive + diuresis ... Transfusion #Reactions #hematology ... diagnosis #comparison #table
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
chemotherapy, etc ... associated with renal ... suspected • Hypercalcemia ... possible malignancy (e.g ... Electrophoresis #SPEP #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Imaging: CXR- pulmonary ... Anaphylaxis, Acute Renal ... Supportive Care: Diuresis ... APML #diagnosis #management ... #hematology #oncology
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
derangements (hyperkalemia ... , hypercalcemia, ... Fluid Overload (pulmonary ... refractory to diuretics ... #Therapy #RRT #managment