18 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
distinction has HUGE treatment ... and first-line treatment ... #purpura #TTP # ... Comparison #Diagnosis #Table ... #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Differential Diagnosis Table ... • Thrombotic Thrombocytopenic ... Purpura (TTP) ... Metabolism-mediated TMA - Coagulation-mediated ... Microangiopathy #TMA #hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Thrombocytopenic ... Purpura (TTP) ... #Purpura #management ... #treatment #rheumatology ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Diagnosis Algorithm Thrombocytopenia ... Rare • Drugs (e.g ... • Vasculitis Coagulation ... deficiencies Coagulation ... Algorithm #Causes #Hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... presents with coagulation ... pregnancy * Severe coagulation ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... presents with coagulation ... pregnancy * Severe coagulation ... AFLP #obstetrics #hematology ... #diagnosis #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... (usually IgG) (e.g ... differential #diagnosis #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... Malabsorption (e.g ... EricsMedicalLectures/ #Coagulation ... Deficiencies #Summary #table ... comparison #diagnosis #hematology