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diagnosis oncology management causes workup algorithm signs chronic erythematosus hemolysis leukemia lupus sle systemic classification cll disorders extravascular hemeonc hemolytic
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... Noncontiguous spread • Clinical ... involvement Differential ... • Other hematologic ... #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes ... IgM associated lymphoma ... , Malignant lymphoma ... RBC #Morphology #differential ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Metastatic cancer, Lymphoma ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Congenital Diseases ... deficiency • Fanconi’s anemia ... • Leukemia • Lymphoma ... #Diagnosis #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... Viral Infection Clinical ... younger pts) Differential ... #hematology #diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... Cold AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... e.g. lupus, CLL, lymphoma ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... , Auer rod • Lymphoid ... Pelger-Huet, Macrocytic anemia ... Myelofibrosis (MF ... Blood #Disorders #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Signs and Symptoms ... but elevated as disease ... bile ducts Differential ... Endocrinopathy, Lymphoma ... diagnosis #workup #hepatology
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