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diagnosis anemia hepatitis algorithm autoimmune causes management hemolysis aiha extravascular intravascular lfts aclf acute aflp agglutinin ah alcoholic atlas blastomycosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... • Cold AIHA ... AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis ... Agglutinin Disease ... Differential #Diagnosis ... #Table #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... , Cold AIHA, Transfusion ... Defects, Drugs, Liver ... Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... )"Cold" (usually ... (e.g. primary cold ... Extravascular #Causes #differential ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... esp if severe disease ... , Splenectomy, MMF ... azathioprine Cold ... Treatment #management #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Cell Agglutinate: Cold ... autoimmune hemolytic ... anemia, Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Extrinsic Causes: • Liver ... disease • Hypersplenism ... • AIHA: warm, ... cold, drug induced ... classification #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral Infection Clinical ... younger pts) Differential ... Hemoglobinuria (PCH ... #hematology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Drugs • AIH ... • Cholestatic disease ... Others #LFTs #Hepatology
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