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hepatology lfts algorithm causes elevation hepatitis hepatocellular abnormal acidosis acute arterial chemistry cholestatic classification dili drug elevated embolism enzymes function
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... • R value = (ALT ... #Cholestatic #Transaminitis ... #diagnosis #differential ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... for Transaminitis ... #Algorithm #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Diagnosis Framework ... injury) • Ischemic ... #Diagnosis #hepatology ... #transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALP ≥ 2x ULN R Value ... Hepatocellular injury ... 2: Cholestatic injury ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... : Liver Injury ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... #Injury #Differential ... #Diagnosis #Causes ... Acute #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... injury < 26 weeks ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
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