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diagnosis hepatology algorithm lfts causes elevation hepatitis management elevated hepatocellular abnormal acidosis acute aih alkaline alp arterial autoimmune biliary chemistry
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... Liver Injury? ... • R value = (ALT ... #Transaminitis ... #diagnosis #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Algorithm for Transaminitis ... def, Wilson's, Cholestatic ... dz Cholestatic
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALP ≥ 2x ULN R Value ... Hepatocellular injury ... injury Sinai ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Thrombus, Vasospasm Cholestatic ... Hepatitis, TB Cholestatic ... #Injury #Differential ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Acute Liver Injury ... #differential # ... diagnosis #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... phosphatase) 2) Cholestatic ... Injury Differential ... #Injury #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... disease • If ... disease: > 2 ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... of Intrahepatic cholestasis ... - Pruritis - Cholestasis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
disease 6-9 mo ... Calculate R-Value ... Mixed DILI • Cholestatic ... #differential # ... gastroenterology #hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... Haptoglobin ↓ - Lactate ... #Diagnosis #hematology
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