25 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... Cell Agglutinate: Cold ... anemia, Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Bleeding / Bruising - Differential ... Sequestration Disordered ... Connective Tissue Disorders ... Iatrogenic) • Liver ... Algorithm #Causes #Hematology
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm
 • GI disorders: Celiac disease, Crohn's disease,
Nephropathy - Differential ... Algorithm • GI disorders ... Ulcerative Colitis • Liver ... myeloma, Lymphomas, RCC ... : COPD, cystic fibrosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... younger pts) Differential ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... practices that could ... disease, decrease ... disease), HBsAg ... Causes #Workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology ... #rheumatology #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... Warm AIHA • Cold ... AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA ... diagnosis #table #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... • Small Bowel Disorder ... • Pancreatic Disease ... Disease #Macrocytic ... Algorithm #Causes #Hematology