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liver transaminitis hematology elevation hepatitis hepatocellular interpretation laboratory abnormal acute alkaline ankle arterial blood chemistry cholestatic classification clinicopathology disorders drug
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Function Test (LFTs ... abnormality vs bone Bili ... ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
) - Causes of Hepatocellular ... • R value = (ALT ... Transaminitis #diagnosis ... #differential # ... hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Vascular Causes ... #diagnosis #algorithm ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... or AST > ALP): ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Others #LFTs ... #Hepatology #LiverEnzymes ... Diagnosis #Algorithm ... #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Diagnosis Algorithm ... Intestine - Other causes ... #Diagnosis #Algorithm ... #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... ) - Normal Values ... hepatocellular injury ... Interpretation #diagnosis ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... Differential Diagnosis ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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