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algorithm bruising management activation arteritis bleeding disorders elevatedmcv gca giantcell hemolysis hemolytic intravascular macrocytic macrocytosis macrophage mas neutropenia peds platelet
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... (usually IgG) (e.g ... (usually IgM) (e.g ... #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Diagnosis Algorithm ... Toxic Damage (e.g ... Diagnosis #Algorithm ... #Causes #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #peds #pediatrics ... #diagnosis #differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Thrombocytopenia ... Rare • Drugs (e.g ... #Diagnosis #Algorithm ... #Causes #Hematology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Diagnosis Algorithm ... Panhypopituitarism Treatment ... #Diagnosis #Algorithm ... #endocrinology ... #causes #pediatrics
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... function test, ANA (e.g ... changes), high MCV anemia ... #Diagnosis #Causes ... #Workup #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Increased Requirement (e.g ... #Diagnosis #Algorithm ... #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... underlying disease (eg ... • Infection (eg ... , and thrombocytopenia ... #Hematology #Rheumatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Constitutional disorders, eg ... Megaloblastic anemia-rare ... #diagnosis #causes ... #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
not be subtle e.g ... very remarkable w/differential ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia ... them, but urgent rheumatology
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