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differential management causes algorithm oncology rheumatology neurology dermatology systemic workup acute chronic erythematosus hemolytic lupus macrocytic mds microscopy myelodysplastic nephrology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... . sickle cell disease ... #hematology #anemia
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... Allogeneic stem cell ... #hematology #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... • Secondary (e.g ... RBCs - Sickle Cells ... , Target Cells ... Algorithm #Causes #Hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
and laboratory diagnosis ... non-specific red cell ... polychromatophilic cells ... count, D-dimer, egg ... #Hematology #Pathology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Chemotherapy (e.g ... Bite Cell RBC: G6PD ... #differential #diagnosis ... #hematology #microscopy
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... • Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... workup #oncology #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
- Diagnosis and ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... adsorption onto cancer cells ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... Intrinsic RBC defects (e.g ... . sickle cell anemia ... #diagnosis #calculation
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