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diagnosis differential erythematosus sle treatment signs symptoms activation acute aki causes cerebritis classification cns conditions cryoglobulinemia cryoglobulins extrarticular hematology joint
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Lumbar Puncture, EEG ... #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... underlying disease (eg ... • Infection (eg ... hypersensitivity syndromes
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... (e.g. oculomotor ... Hypothalamic or thalamic syndromes ... AQP4-lgG disease; e.g ... , Sjögren syndrome
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
vasoconstriction (e.g ... inhibitors, hepatorenal syndrome ... Secondary GNs: Due to systemic ... Post-infectious GN, Lupus ... AIN) • Drugs (e.g
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... Endocrine disorders (e.g ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome ... tissue disorder (e.g ... . systemic lupus
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
GI - Felty syndrome ... • Felty's syndrome ... Shrinking lung syndrome ... - SLE Neurologic ... disease, Vasculitis (e.g
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... electromyographic (EMG ... Differential #Diagnosis #neurology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... lupus erythematosus ... antisynthetase syndrome ... Lambert-Eaton myasthenic syndrome ... (SAMS-CI) • EMG
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