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diagnosis management candida antifungal infectiousdiseases pharmacology treatment antibiotics auris candidiasis candiduria fungal fungemia overview polyenes review abelcet algorithm ambisome amphoterecinb
Candida Glabrata Species of Candida Most Commonly Isolated in Bloodstream Infections • Symptomatic mucosal infection is detected
• Candiduria ... organ systems & candidemia ... has efficacy in candiduria ... option, consider echinocandin ... possible when candidemia
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup ... Antibiotics • Empiric: Echinocandins ... CVL/PICC) - If candidemia ... iMedEducation #Candidemia
Candiduria on Urine Microscopy - Yeast/Blastoconidium - Pseudohyohae - Hyphae Carlos Martínez Figueroa @CarlosMartnezF7 #Candiduria #Urine #Microscopy #clinical
Candiduria on Urine ... CarlosMartnezF7 #Candiduria
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... monotherapy) All Echinocandins ... Review #Overview #Echinocandins
Algorithm for Evaluation and Treatment of Asymptomatic Candiduria Evidence for disseminated candidiasis, Unstable or neutropenic patient 1. fluconazole
of Asymptomatic Candiduria ... flucytosine #Candiduria
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
infections: - Echinocandins
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Triazoles #Polyenes #Echinocandins
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and
infections – because echinocandins
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
with AFST) • Echinocandin
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
aminoglycosides, echinocandins
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