38 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... IFN-y) → Excessive activation ... Autoimmune diseases: SLE ... #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE ... CNS #neurology #rheumatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... sequestration and activation ... : 33% • Treatment ... : No • Treatment ... #diagnosis #comparison
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
• Specific for SLE ... severe disease Treatment ... Erythematosus #SLE ... #Summary #diagnosis ... #rheumatology #
Olecranon Bursitis - Often due to repetitive microtrauma

Inflammatory vs Septic
Clinical Features, Lab Aspirate and Treatment
BOTH CAN
Olecranon Bursitis ... Lab Aspirate and Treatment ... MORE HOT #Diagnosis ... #Management #Elbow ... #Olecranon #Bursitis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... ) - Diagnosis and ... life-threatening • Treatment ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... erythematosus [SLE ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... complex → plt activation ... Confirmatory test ↑Se ... #Management #Treatment ... #Hematology #HemeOnc
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... Erythematosus (SLE ... life-threatening • Treatment ... comparison #table #rheumatology ... #diagnosis #management
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
/full triad at diagnosis ... Can also see mechanics ... after 2 years of treatment ... Autoimmune #Myositis #diagnosis ... #rheumatology