26 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Heart Valve) #Thrombocytopenia ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... of thrombocytopenia ... #Workup #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Differential Diagnosis Algorithm ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
phagocytophilum Pathophysiology ... ), cough (30% cases ... immature forms) • Anemia ... and thrombocytopenia ... • Elevated transaminases
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... with elevated Mean ... Differential Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... Cardio-pulmonary disease • Anemia ... muscle involvement, elevated ... Peripheral #Weakness #Neurology ... #Causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
fibrinogen • Elevated ... protein C and S Pathophysiology ... Treat primary cause ... #treatment #management ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Normal or slightly elevated ... result in severe anemia ... immune hemolytic anemia ... Diagnosis #Workup #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... Lysis Syndrome: • Pathophysiology ... TLS #diagnosis #management ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... infections/fevers • Thrombocytopenia ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management