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management differential erythematosus lupus systemic symptoms workup thrombocytopenia treatment vasculitis arthritis autoantibodies neurology summary syndrome activation algorithm ana antimda5 antimda5dm
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... • Specific for SLE ... Erythematosus #SLE ... #Summary #diagnosis ... #rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
involvement 3% SLE-Related ... sclerosis, Still's disease ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
is a skin prick test ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs ... #symptoms #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... K), H. pylori test ... thyroid function test ... , ANA (e.g., SLE ... Causes #Workup #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... clinically suspected, tests ... with auto-immune diseases ... erythematosus #diagnosis ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Cerebrovascular Disease ... , PRES Pathophysiology ... Erythematosus #SLE ... CNS #neurology #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Erythematosus #Diagnosis ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... treatment #summary #rheumatology
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