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causes management anemia syndrome algorithm chronic hodgkins lymphocytic lymphoma mds myelodysplastic thrombocytopenia treatment workup agglutinin apml basophilia basophils classification cold
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... ) CLL Symptoms: ... #Hematology #Oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... ITP • SLE • CLL ... Vasculitis • Infection ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... lymphoproliferative disorders ... aplasia • ITP ... #oncology #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... : • Recurrent infections ... to MDS or acute leukemia ... management #treatment #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... Etiology: - Infections ... Diagnosis of B-Symptoms ... #oncology #diagnosis ... hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Diagnosis Framework ... Myeloproliferative Disorders ... Diabetes/DKA Infections ... : • helminth infections ... #hematology #basophils
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... risk-stratification • Risks: infection ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... Infectious • ... • Lymphoma • Leukemia ... Myeloproliferative disorders ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... (CML) - Dr. ... #hematology #secondary
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Check For: • Infections ... Polyclonal IgM post infectious ... hemolytic #anemia #hematology
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