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differential ana antinuclear autoantibodies erythematosus lupus management disease signs symptoms table workup associations causes classification diseases patterns syndrome thrombocytopenia acute
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... Vasculitis: • ... + 60% • Eosinophilic ... #diagnosis #rheumatology
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... Vasculitis There ... StanfordChiefs #ANCA ... #diagnosis #algorithm ... #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... Vasculitis: P-ANCA ... #diagnosis #associations
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... purpura: strong sign ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... erythematosus (SLE ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Purpura Anti-GBM antibodies ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... erythematosus (SLE ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... diseases, such as SLE ... purpura: Strong sign ... Polyangiitis): • Eosinophilia ... #Rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... HUS • DIC • Vasculitis ... #Hematology
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