31 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... #diagnosis #types
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
seen in 30—70% of cases ... • Sjögren syndrome ... Vasculitis: • ... Renal-limited vasculitis ... Antineutrophil #antibodies #diagnosis
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... - Differential Diagnosis ... complex mediated (cryoglobulins ... , IgA), ANCA associated ... #vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... Differential Diagnosis ... Serologies for Cryoglobulins ... differential #diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-SSB (La) - Sjogren's ... - Vasculitis, e.g ... granulomatosis p-ANCA ... - Vasculitis, e.g ... Associations #diseases #diagnosis
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anticoagulant (LAC) • Sjogren ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA ... #Rheumatology #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... osmolarity If cause ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... immunoglobulins, cryoglobulins
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Vasculitis of ... small vessels - ANCA-associated ... disease - Sjögren ... #Vessels #Diagnosis ... #Rheumatology #Diagnosis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... • Secondary Causes ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE, Sjogren's ... #Differential #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... (C-ANCA): GPA > ... (P-ANCA): eGPA, ... Glomerulonephritis #Vasculitis ... #differential #diagnosis