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diagnosis hematology differential causes hemolytic aflp algorithm extravascular hellp obstetrics pregnancy purpura ttphus workup atlas classification hemolyticuremicsyndrome key microangiopathy morphology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... syndrome (HUS) ... #Hemolytic #Intravascular
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
and Intravascular ... anemia • ... • MAHA (TTP ... , DIC, HUS) ... Algorithm #Causes #Hematology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Microangiopathy #thrombocytopenic ... HemolyticUremicSyndrome #HUS ... #thrombocytopenia ... #Comparison #Diagnosis ... #Table #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia ... /HUS, HELLP Syndrome ... defects. 1) HELLP (Hemolysis ... #diagnosis #table ... #comparison
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... , HUS, aHUS, mechanical ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
spherocytosis, Hemolytic ... Thrombotic idiopathic thrombocytopenia ... (ITP), Disseminated ... intravascular coagulopathy ... #differential #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... IVIG infusion Intravascular ... Causes: • MAHA: TTP ... , HUS, DIC, HELLP
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... for Thrombotic Thrombocytopenic ... reflection of intravascular ... anemia Indirect ... impairment #TTP
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia ... defects. 1) HELLP (Hemolysis ... of child 3) TTP ... #Diagnosis #Comparison ... #Table
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP ... /HUS - Hemolytic ... anemia - Splenomegaly ... Defects: • DIC, TTP ... /HUS • Anticoagulants
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