13 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
- TTP VS HUS ... implications : TTP ... #purpura #TTP # ... #Comparison #Diagnosis ... #Table #Hematology
Thrombotic Thrombocytopenic Purpura (TTP) vs Disseminated Intravascular Coagulation (DIC)
#Diagnosis #TTP #DIC #Comparison #Table #Laboratory #Findings #RebelEM
Thrombotic Thrombocytopenic ... Purpura (TTP) vs ... ) #Diagnosis #TTP ... #DIC #Comparison ... #Table #Laboratory
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Primary Thrombotic Microangiopathy ... Differential Diagnosis Table ... • Thrombotic Thrombocytopenic ... Purpura (TTP) ... #TMA #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Consumption: - Microangiopathy ... : DIC, TTP, HUS ... Antibody-mediated: ITP ... Diagnosis #Framework #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... : ITP • Secondary ... /TTP/HUS - Hemolytic ... , TTP/HUS • Anticoagulants ... #nonpalpable #dermatology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Purpura (TTP) ... Diagnosis of TTP ... • Distinguish TTP ... TMA: Thrombotic microangiopathy ... of TTP: • Consider
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
triad of MAHA + thrombocytopenia ... TMA is due to TTP ... TTP is only TMA ... suggests against TTP ... #diagnosis #ttp
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Mechanical Trauma (Microangiopathic ... intravascular coagulation (DIC ... : Thrombotic thrombocytopenic ... purpura (TTP), ... uremic syndrome (HUS
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Pregnancy - TTP ... /HUS, HELLP Syndrome ... schistocytes, DIC ... plasma exchange 2) TTP ... #comparison
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Petechiae • Purpura ... DDX: • TMA’s (HUS ... /TTP/DITMA) - ... Schistocytes - MAHA: TTP ... /HUS > DIC • Severe