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Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia Classification ... : Monoclonal IgM ... 2: Monoclonal IgM ... Cryoglobulinemia #Classification ... #Types #hematology
Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis Classification ... Algorithm #Lupus ... #Algorithm #diagnosis ... #differential #types ... #rheumatology #
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Manifestations of Monoclonal ... Autoantibody activity: Type ... cryoglobulinemia, Cold ... NaderYatim #monoclonal ... manifestations #dermatology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
precipitate with cold ... characterized into 3 types ... arterioles) MONOCLONAL ... CRYOGLOBULINEMIA (type ... Vasculitis #Diagnosis #Rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Disease 3 Types ... - Idiopathic monoclonal ... malignancy (CLL) - Monoclonal ... Such As: • IgM monoclonal ... hemolytic #anemia #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
Suggested algorithm ... patients with monoclonal ... low-risk MGUS (IgG type ... #monoclonal #gammopathy ... diagnosis #management #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... Cryoglobulins: - Single monoclonal ... - Composed of monoclonal ... #classification ... #rheumatology #
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... meet criteria for hematologic ... or evolve into hematologic ... guide subtype classification ... vasculitis Types