Extrapyramidal antiemetics

Effects of prophylactic anticholinergic medications to decrease extrapyramidal side effects in patients taking acute antiemetic drugs:

medications to decrease extrapyramidal ... patients taking acute antiemetic ... are seen when antiemetic ... Anticholinergics #Extrapyramidal ... #EPS #Antiemetics

Antiemetics and Vomiting

#Pathophysiology #Antiemetics #Locations #Action #Pathways #Nausea #Chemotherapy #TriggerZone #CTZ

Antiemetics and ... Pathophysiology #Antiemetics

TYPES OF CEREBRAL PALSY AND AREAS OF BRAIN DAMAGE INVOLVED
Hemiplegia
Diplegia
Quadriplegia
Athetoid
Dystonic
Ataxic

Classification #Extrapyramidal

Motor Syndromes of Cerebral Palsy:

Spastic Hemiplegia, Spastic diplegia, Spastic quadriplegia (‘total body involvement’), Athetoid (extrapyramidal, dyskinetic)

#Diagnosis

involvement’), Athetoid (extrapyramidal

AtypicaI) Listed by Extrapyramidal

Causes of Dementia / Cognitive Impairment - Differential Diagnosis Algorithm

Affecting Multiple Domains
• Depression
• Delirium
Decline

Dementia - Early Extrapyramidal ... Dementia • Early Extrapyramidal

Hidden anticholinergics in elderly patients: What, where and how?

Antihistamines - 1st generation: chlorpheniramine, hydroxyzine, diphenhydramine
Antidepressants

orphenadrine Antiemetics

Medications causing Acute Kidney Injury (AKI)
Prerenal:
• Dehydration: Diuretics
• Altered intrarenal autoregulation: ACEIs / ARBs,

TCAs, SSRIs, some antiemetics

Common Medications Known to Prolong QTc
Antiarrhythmics - Amiodarone, sotalol, flecainide, quinidine, dronedarone, dofetilide
Vasopressors/inotropes - Epinephrine, norepinephrine,

metoclopramide Antiemetics

Intern Pocket Cards - Inpatient Anti-Emetics Guide
Serotonin antagonists:
• Ondansetron (Zofran), Granisetron (Kytril, Sancuso) - Headache,

pocketcardset #nausea #antiemetics

increasing signs of extrapyramidal

First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block

-> Striatum -> Extrapyramidal

Pisa Syndrome (pleurothotonus) on Physical Exam
A tonic flexion of the trunk of the body to one

neuroleptics, antiemetic

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Neuroleptic Malignant Syndrome - Diagnosis
Neuroleptic Malignant Syndrome is an idiosyncratic reaction to antipsychotic medications classically characterized

antipsychotics) - Antiemetics

Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,

accumulation], extrapyramidal

Common Antiemetic Dosing Regimens
Serotonin 5-HT3 Antagonists - Ondansetron Granisetron, Dolasetron, Palonosetron
Corticosteroids - Dexamethasone, Methylprednisolone
Dopamine Receptor

Common Antiemetic ... palonosetron #Antiemetic

that occurs in extrapyramidal

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Ondansetron for Antiemetic

Symptoms and Signs of Hypocalcemia
Muscular: Weakness, fatigue, Spasms, cramps
Neurologic: Tetany, Chvostek sign, Trousseau sign, Circumoral and

dementia, seizures, Extrapyramidal

Differential Considerations for a Seizure or Seizure-like Event
The following diagnoses may have presentations that can be

overanalgesia - Extrapyramidal

Cyclic Vomiting Syndrome - Treatment
Acute Treatment:
• Abortive Therapy: Sumatriptan (5-HT / serotonin agonist), Aprepitant (neurokinin

Minimal stimulation, Antiemetics

Malignant Pericardial Effusion and Tamponade on POCUS Echocardiogram - A4C
CA patient with known pericardial effusion who

IV fluids and antiemetics

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Serotonin Syndrome: Pathogenesis and Clinical Findings
Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and

lithium), opioids, antiemetic

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