2129 results
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Von Willebrand’s disease ... Von Willebrand disease ... Von Willebrand disease ... deficiency • Liver disease ... Acquired: • Liver disease
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... von Willebrand factor ... with relevant factor ... those with severe disease
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Pathogenesis and risk factors ... Leukemia) • GI diseases ... liver or kidney disease ... • Lifestyle Factors
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... Deficiency of Factor ... Malabsorption (e.g. celiac disease ... Advanced Liver Disease ... Autoimmune • Factor
Posterior Reversible Encephalopathy Syndrome (PRES) - Diagnosis
Clinical Features:
 • Altered mental status (Either lethargy, confusion, or
blindness) Risk Factors ... • Autoimmune disease ... Diagnosis: Risk Factor
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Contact pathway factors ... Decreased factor ... Factor consumption ... Factor X deficiency
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
ASA) • Renal Disease ... Congenital • Factor ... Deficiency • Factor ... Von Willebrand's Disease ... Iatrogenic) • Liver Disease
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
(warfarin) • Factor ... inhibitor • Liver disease ... Heparinized line • Factor ... test tubes • Factor
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Anti-CCP, Rheumatoid factor ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... Findings Risk factor ... E4 allele Risk factors