23 results
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... Reduced levels of factors ... protein C and S Pathophysiology ... venipuncture sites Laboratory ... treatment #management #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
(warfarin) • Factor ... elevated in: • DIC ... test tubes • Factor ... Thromboplastin #laboratory ... #hematology #diagnosis
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... inhibitor of normal factor ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation (DIC ... of coagulation factors ... of thrombin and factor ... Scoring #diagnosis #hematology ... #laboratory
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Decreased factor ... intravascularcoagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... Deficiency of Factor ... Post-partum • Acute DIC ... Summary #table #comparison ... #diagnosis #hematology
Approach to a Positive (+) Rheumatoid Factor (RF)
(+) RF does not always = RA
Rheumatic disorders:
 •
(+) Rheumatoid Factor ... #Rheumatoid #Factor ... #RF #rheumatology ... #laboratory #differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... MAHA: TTP, HUS, DIC ... Hypophostphatemia Laboratory ... #Hemolysis #Differential ... #Diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... Warfarin • Acute DIC ... disease • Acute DIC ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Decreased factor ... Factor consumption ... intravascular coagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation