31 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... of anemia and hemolysis ... Reticulocytes • Abnormal ... #Anemias #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
with Normal Mean ... PRV, Chronic) Normal ... Polychromatic Macrocytes, Normal ... - Abnormal RBCs ... Hemoglobinopathy - Normal
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Drug-induced AIHA - Abnormal ... anemia • ... Extravascular #Differential ... Algorithm #Causes #Hematology
Hoffmann's Sign

Hoffman's sign means upper motor neuron injury.  The Hoffmann's reflex test itself involves loosely
holding the middle finger ... allowing the middle finger ... Reflex #Positive #Abnormal ... #clinical #video ... #neurology #physicalexam
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Chronic Disease Normal ... • Bleeding • Hemolysis ... Classification #Differential ... Algorithm #Causes #Hematology
Hoffman's sign. Even in this specific case, accompanied by a clonus outline (rhythmic contractions). The median
Hoffman's sign. ... #Hoffmanns #Sign ... Reflex #Positive #Abnormal ... #clinical #video ... #neurology #PhysicalExam
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
nose, ears, or fingers ... of anemia include ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... Blood Smear ↑ abnormal ... #Differential # ... Diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
levels - Usually normal ... products or D-dimer - Normal ... result in severe anemia ... anemia Indirect ... WBC count and differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... upon damage • Normal ... anemia, PNH, immune ... associated with any symptoms ... Dehydrogenase #Elevated #differential