37 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... and Platelet Disorders ... changes), high MCV anemia ... #Platelet #Disorders ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... : - Thrombocytopenia ... - Hemolytic anemia ... #Differential #Diagnosis
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia ... - Differential Diagnosis ... Connective tissue disorders ... #Algorithm #hematology ... #platelets
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Algorithm Thrombocytopenia ... Platelet Function ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
• Rheumatic disorders ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Algorithm #Causes ... #Hematology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
Causes of Purpura ... Congenital - Rare disorders ... bypass Vascular disorders ... Purpura #Bruising #Causes ... peds #pediatrics #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... Megakaryopoiesis • Aplastic Anemia ... #Algorithm #Causes ... #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
inherited bleeding disorder ... bruising • Skin ... Laboratory • Normal platelet ... count (mild thrombocytopenia ... VonWillebrand #Disease #Diagnosis
Skin Hypopigmentation - Differential Diagnosis Algorithm

Diffuse Congenital - Generalized hypopigmentation of hair, eyes, skin
 • Phenylketonuria
- Differential Diagnosis ... Algorithm Diffuse ... Hypopigmentation #disorders ... #skin #dermatology ... #Algorithm #causes
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder