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diagnosis hematology oncology algorithm causes syndrome chronic cll lymphocytic mds myelodysplastic activation apl auer auerrods behcet blood bloodsmear bruising ckd
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Leukemia, Tumour ... Autoimmune • ITP • SLE
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... to MDS or acute leukemia ... #management #treatment ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... virus (EBV) • Leukemia ... anemia Treatment ... #management
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Chronic Myelogenous Leukemia ... effect following treatment ... following EtOH induced thrombocytopenia ... Iron deficiency anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... #treatment #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
) - SLE ( ... Acquired - Aplastic ... infiltration (e.g. leukaemia ... Henoch—Schönlein purpura, SLE ... pediatrics #diagnosis #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... or thrombocytopenia ... or thrombocytopenia ... #oncology #hematology ... hemeonc #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... • Neutropenia, anemia ... , thrombocytopenia ... Pure red cell aplasia ... microglobulin Treatment
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... 6.8 g/dL), and thrombocytopenia ... bilobed nuclei, fine ... She was admitted ... hospitalization and treatment
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 Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... blood count with differential
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