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diagnosis differential algorithm iron anemia msk pain pathophysiology rheumatology thrombocytosis thrombosis venous arthritis b12 cardiology clots cobalamin dermatology embolism extremity
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... disorders • Celiac disease ... malignancy • Iron deficiency ... Diagnosis #Algorithm #Causes
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... Lipoprotein a ↑ - IBD ... APLS:PLT ↓ HEMATOLOGIC ... Diagnosis #clots #hematology
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Edema, Celiac disease ... (IBD, cancer) ... #Iron #Deficiency ... #nutrition
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... , Chronic disease ... #Causes #differential ... diagnosis #anemia #nutrition
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Protein S deficiency ... Myeloproliferative disease ... Ischemic Liver, IBD ... coagulation and other causes ... pathophysiology #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Structural: Celiac disease ... Tropical sprue, IBD ... Bypass surgery, Bacterial ... Algorithm #ferritin #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Acute hemolysis, deficiency ... Vasculitides, IBD ... , Celiac disease ... infections, TB, Acute bacterial
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD ... necrosis) • VIT K deficiency ... EGPA - MPA • CTD ... gangrenosum • Bacterial ... Differential #Diagnosis #hematology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
• Severe iron deficiency ... Chronic pulmonary diseases ... Arteriovenous fistula ... coronary heart disease ... Worse outcomes in CKD
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Legg-Calve-Perthes disease ... • Bursitis • IBD ... ulcers, Edema Arterial ... Vit B12, B6, Cu deficiency ... lower #extremity #msk
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