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diagnosis differential hematology algorithm aafp aiha ascorbicacid atlas bloodcell causes cirrhosis extravascular folate folicacid hemolysis hepatology homocysteine index intravascular macrocytic
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... BrighamMedRes #AIHA #Autoimmune ... #Hemolytic #Anemia ... #Pathophysiology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
, Vitamin B12, Folate ... Retroperitoneal, Uterine • Hemolysis ... : Autoimmune, Microangiopathic ... hemolytic anemia ... differential #diagnosis #calculation
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... -100): • Non-hemolytic ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Megaloblastic: Folate
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Cold AIHA • Alloimmune ... within circulation ... anemia •
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Vitamin B12 or Folate ... spherocytosis, Autoimmune ... hemolytic anemia ... Agglutinate: Cold autoimmune ... hemolytic anemia
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... Hemorrhage or hemolysis ... elevated, but anemia ... but undiagnosed, folate ... #VitaminB12 #Folate
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... Vitamin B12 • Folate
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... B12 deficiency, Folate ... syndrome, Spur cell anemia ... , Autoimmune hemolytic ... anemia, Hemolysis
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
breath, wasting, anemia ... Loss of teeth Anemia ... lead to iron and folate ... contribute to nonimmune hemolysis ... #AscorbicAcid #Pathophysiology
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