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diagnosis differential hematology algorithm causes nutrition folate folicacid mcv aafp ascorbicacid atlas bloodcell cardiology cirrhosis classification decrease dm2 elevation extravascular
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... , Vitamin B12, Folate ... Microangiopathic hemolytic ... , G6PD deficiency ... differential #diagnosis #calculation
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
-100): • Non-hemolytic ... , CKD • Hemolytic ... Megaloblastic: Folate ... deficiency, B12 ... deficiency, Orotic
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... Defects • G6PD deficiency ... • PK deficiency ... within circulation ... anemia •
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Vitamin B12 or Folate ... deficiency, Liver ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Hemorrhage or hemolysis ... if vitamin B12 deficiency ... but undiagnosed, folate ... occur with B12 deficiency ... #VitaminB12 #Folate
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... 80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... 100 fL) • B12 Deficiency ... • Folate Deficiency
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... pregnant have hemolytic ... anemia, or psoriasis ... deficiency are ... deficiency.
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... deficiency • ... Hypertriglyceridemia • Uremia ... blood loss • Hemolytic ... anemia • Splenomegaly
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis ... Vitamin B12 • Folate ... deficiency Infections
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... • Vitamin E - Haemolytic ... anaemia, ataxia ... paraesthesiae • Folate ... #Vitamins #Deficiency
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