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diagnosis causes algorithm hemolysis liver workup extravascular injury intravascular transaminitis alkaline alp anemias chemistry classification disorders hepatitis hyophosphatasia interpretation low
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... Membrane defects, Enzyme ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Hemoglobin - Enzyme ... #Anemia #Differential ... Diagnosis #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Intrinsic RBC Defects: Enzyme ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... elliptocytosis - RBC Enzyme ... anemia • ... Extravascular #Differential ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Intrinsic Causes: • Enzyme ... #Anemia #Differential ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... deficiency, Other enzyme ... #Anemia #Differential ... Algorithm #workup #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Spiders - Enzyme ... Defects: Sickle cell anemia ... #Differential # ... Diagnosis #hematology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
2-5x normal - Hemolysis ... , NASH, Genetic ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... result in severe anemia ... anemia Indirect ... WBC count and differential ... Diagnosis #Workup #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Source of Liver Enzyme ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
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